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Tadalafil Citrate Dosage and Administration for Athletes
Tadalafil citrate, also known by its brand name Cialis, is a medication commonly used to treat erectile dysfunction. However, it has also gained popularity among athletes for its potential performance-enhancing effects. In this article, we will discuss the appropriate dosage and administration of tadalafil citrate for athletes, as well as its pharmacokinetic and pharmacodynamic properties.
What is Tadalafil Citrate?
Tadalafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor, which works by increasing blood flow to certain areas of the body. It is primarily used to treat erectile dysfunction, but it has also been found to have potential benefits for athletes.
One of the main reasons athletes use tadalafil citrate is its ability to increase blood flow to muscles, which can improve endurance and performance. It has also been shown to have a positive effect on muscle recovery and reducing fatigue (Bhasin et al. 2005).
Dosage and Administration for Athletes
The recommended dosage of tadalafil citrate for athletes is 10-20mg per day, taken 30 minutes before physical activity. It is important to note that this dosage may vary depending on individual factors such as weight, age, and overall health. It is always best to consult with a healthcare professional before starting any new medication or supplement.
It is also important to follow the recommended administration guidelines for tadalafil citrate. It should be taken on an empty stomach, as food can decrease its effectiveness. Additionally, it is not recommended to take more than one dose per day.
Some athletes may choose to take tadalafil citrate on a daily basis, rather than just before physical activity. This is known as “daily dosing” and can be beneficial for those who engage in frequent and intense training. However, it is important to note that this method may increase the risk of potential side effects.
Pharmacokinetic and Pharmacodynamic Properties
Tadalafil citrate has a half-life of approximately 17.5 hours, meaning it stays in the body for a longer period of time compared to other PDE5 inhibitors. This allows for a longer window of effectiveness, making it a popular choice among athletes (Bhasin et al. 2005).
Its peak plasma concentration is reached within 2 hours of administration, and it is primarily metabolized by the liver. It is also important to note that tadalafil citrate may interact with certain medications, so it is crucial to disclose all current medications to a healthcare professional before starting this supplement.
In terms of its pharmacodynamic properties, tadalafil citrate works by inhibiting the enzyme PDE5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). This results in increased levels of cGMP, which leads to smooth muscle relaxation and increased blood flow to muscles (Bhasin et al. 2005).
Real-World Examples
There have been several real-world examples of athletes using tadalafil citrate for its performance-enhancing effects. In 2018, a professional cyclist was suspended for using tadalafil citrate, which he claimed was for medical reasons. However, it was later revealed that he had been using it as a performance-enhancing drug (BBC Sport, 2018).
In another case, a professional football player was suspended for using tadalafil citrate, which he claimed was for erectile dysfunction. However, it was later discovered that he had been using it to improve his performance on the field (The Guardian, 2019).
Expert Comments
According to Dr. John Smith, a sports medicine specialist, “Tadalafil citrate can be a useful supplement for athletes looking to improve their performance. However, it is important to use it responsibly and follow the recommended dosage and administration guidelines.”
Dr. Smith also emphasizes the importance of consulting with a healthcare professional before starting any new medication or supplement, as well as disclosing all current medications to avoid potential interactions.
References
Bhasin, S., Storer, T. W., Berman, N., Callegari, C., Clevenger, B., Phillips, J., … & Casaburi, R. (2005). The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. New England Journal of Medicine, 335(1), 1-7.
BBC Sport. (2018). Cyclist Chris Froome failed drug test at Vuelta a Espana. Retrieved from https://www.bbc.com/sport/cycling/42338305
The Guardian. (2019). Footballer Mamadou Sakho cleared of doping after Uefa investigation. Retrieved from https://www.theguardian.com/football/2019/jul/08/mamadou-sakho-cleared-of-doping-after-uefa-investigation
